CBD binds weakly to the CB1 receptor and only when THC is present. THC binds to CB1 receptors in the brain and causes feelings of euphoria or ‘a high’. Although both compounds interact with the body’s endocannabinoid system, the effects of these two compounds are very different. Understanding CBD and THCĬannabidiol (CBD) and tetrahydrocannabinol (THC) are both natural compounds found in plants of the Cannabis genus. The following sections provide guidance to help understand how the ratio of CBD:THC works so that going forward you can improve the effectiveness of medicinal cannabis. Understanding which combination to use on individual patients is challenging. These combinations range from CBD-dominant to THC-dominant, for example, CBD:THC 20:1 through to CBD:THC 1:10. However, a broader range of CBD:THC combinations are being investigated to treat other indications, such as pain, epilepsy, anxiety, sleep disorders, etc. Sativex contains equal amounts of CBD and THC (a 1:1 ratio). This is for use as an add-on treatment for the symptoms of moderate to severe spasticity due to multiple sclerosis (MS). As popularity grows, research is being done to further understand the therapeutic benefits of different combination formulations and doses.Ĭurrently, in New Zealand, only one medicinal cannabis product (Sativex) has been approved by Medsafe. With the increased use of these medicines, the CBD:THC ratio is becoming more important. The use of cannabis for medicinal purposes is becoming more and more accepted throughout many countries.
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